منابع مشابه
Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
Recent analysis of genomic signatures in mammals, flies, and worms indicates that functional translational stop codon readthrough is considerably more abundant in metazoa than previously recognized, but this analysis provides only limited clues about the function or mechanism of readthrough. If an mRNA known to be read through in one species is also read through in another, perhaps these questi...
متن کاملPTC IntegrityTM Process DirectorTM
• The unique PTC Integrity Process Perspective best practices in systems and software engineering There are a number of options for documenting your organization’s operational, systems engineering, and software development processes. While certain approaches–like having large printed documents and complex intranet sites–can certainly document your methods, they are expensive to research, update...
متن کاملA reporter system for translational readthrough of stop codons in human cells
Agents to induce readthrough of premature termination codons (PTCs) are useful research tools and potential therapeutics. Reporters used to detect PTC readthrough are gene-specific and thus are not suited to for general assessment of readthrough activity or in cases where PTC-inactivated genes are unknown. Here we describe a GFP-based reporter construct pMHG-W57* which is capable of detecting d...
متن کاملRepair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons.
About 12% of human genetic disorders involve premature termination codons (PTCs). Aminoglycoside antibiotics have been proposed for restoring full-length proteins by readthrough of PTC. To assess the efficiency of readthrough, we selected homozygous and compound heterozygous skin fibroblasts from xeroderma pigmentosum (XP) patients with different PTCs in the XPC DNA repair gene. XP patients hav...
متن کاملAminoglycoside-stimulated readthrough of premature termination codons in selected genes involved in primary ciliary dyskinesia
Translational readthrough of premature termination codons (PTCs) induced by pharmacological compounds has proven to be an effective way of restoring functional protein expression and reducing symptoms in several genetic disorders. We tested the potential of different concentrations of several aminoglycosides (AAGs) for promoting PTC-readthrough in 5 genes involved in the pathogenesis of primary...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2013
ISSN: 1945-3477
DOI: 10.1038/scibx.2013.779